🧠 History of PET Scan (Positron Emission Tomography)
Positron Emission Tomography (PET) is a powerful imaging tool that provides functional/metabolic imaging of tissues, especially useful in oncology, cardiology, and neurology. Here's a brief timeline and development of PET scan technology:
🔬 Key Milestones in PET Scan Development
✅ 1930s–1950s: Theoretical Foundations
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1930s: Positrons (anti-electrons) were discovered by Carl Anderson.
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1940s–1950s: First radionuclides emitting positrons (like Carbon-11, Nitrogen-13) were produced using cyclotrons.
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1950s: Scientists like Gordon Brownell and Charles B. Bender began exploring the use of positrons in imaging.
✅ 1960s–1970s: Concept to Reality
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1961: First tomographic images of positron annihilation were developed.
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1970s: PET technology started advancing with the development of the first PET scanners by scientists like Michael E. Phelps, Edward Hoffman, and Michael Ter-Pogossian.
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1974: First PET brain scanner was built (PETT II).
✅ 1980s–1990s: Clinical Use Begins
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PET imaging began to be used clinically, primarily in brain and cardiac research.
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Development of FDG (Fluorodeoxyglucose) — a glucose analog labeled with Fluorine-18 — made PET highly useful in oncology.
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FDG-PET became standard for detecting cancer metabolism.
✅ 2000s–Present: PET/CT and PET/MRI
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2000s: Introduction of PET/CT scanners — combines functional and anatomical imaging.
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2010s–present: Emergence of PET/MRI machines and development of new radiotracers for specific diseases (e.g., Alzheimer’s, Parkinson’s, prostate cancer).
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| HISTORY OF PET CT SCAN |
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FDG-18 (Glucose metabolism) – cancer
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NaF-18 (Bone scan)
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Ga-68 DOTATATE – neuroendocrine tumors
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PSMA PET (Prostate-specific) – prostate cancer
🏥 Modern Applications
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Oncology: Tumor detection, staging, recurrence
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Cardiology: Myocardial viability
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Neurology: Epilepsy, dementia (e.g., Alzheimer’s disease)
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Infection/Inflammation Imaging
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